Dear Cecil: Recently, a safety poster at work published the following information: “Myth: People who abstain from alcohol are alcohol-free, and can’t be arrested for DUI. Fact: False. People continuously produce alcohol inside their own bodies, a process called endogenous ethanol production. In some cases, enough alcohol can be produced to lead to intoxication.” What?! You mean even if I’m the designated driver, I’m still running the risk of getting a DUI? Help me out, Cecil; I’m considering going back to my skateboard to avoid a bio-induced drunk-driving accident. Jerrod, Augusta, Georgia
You have to wonder what goes on in the minds of the people who write safety posters. One of the little researchers reports seeing a poster at school warning that a commuter train “weighs 5x more than all the players in the NFL combined,” the thought evidently being that a significant fraction of adolescents doesn’t know getting hit by a train could hurt. Similarly, what message are you supposed to draw from the poster you cite – you could get wasted just sitting there, so you might as well drink up?
Endogenous ethanol (EE) production is a normal phenomenon, but except in rare cases the amounts are minute. Studies of healthy abstainers peg blood alcohol concentration (BAC) from EE at less – often much less – than .004 percent, which itself is only a 20th of the usual U.S. legal limit of .08 percent.
Where does EE come from? While there’s some evidence that small amounts are formed inside cells as metabolic intermediaries or products, mostly it’s manufactured in the mobile fermentation vat known as your gut. Some of the tiny things that live in there, especially yeasts, are constantly munching ingested carbs and churning out booze. The body absorbs this normally modest volume of EE and it goes straight to the liver, where it’s metabolized. Barring unusual circumstances, very little EE makes it to the rest of the body.
To get a significant BAC from EE alone would require increased fermentation, diminished ability to metabolize alcohol, or (probably) both. In Japan since the 1950s there have been dozens of published case reports of people feeling drunk after eating carbs such as rice, a condition called meitei-sho or, in English, auto-brewery syndrome. You’re thinking: great – free sake. Not quite. It comes with a price.
In almost every case in one review, intestinal overgrowth of candida or other yeasts was identified as the cause. Most patients had undergone some sort of gastrointestinal surgery – such procedures sometimes result in increased fermentation thanks to blind loops left in the intestine, where microbes can eat and multiply undisturbed. In most cases not involving prior surgery, some other abnormality was noted, such as low stomach acidity.
Auto-brewery syndrome has never been convincingly reported outside Japan. Why? It’s all about enzymes. When the liver processes ethanol, the enzyme alcohol dehydrogenase first converts it to acetaldehyde. In most people a second enzyme, aldehyde dehydrogenase (ALDH), quickly converts the acetaldehyde to harmless acetate. But roughly 50 percent of Japanese and other east Asians and some American Indians (but practically no Europeans or Africans) have a mutated gene that impairs ALDH activity. In these people, even a modest dose of alcohol, imbibed or endogenous, leads to acetaldehyde buildup and unpleasant symptoms: facial flushing, palpitations, dizziness, nausea, headache, and confusion. As acetaldehyde builds up, some is converted back to ethanol, retarding BAC decline. Eventually various enzymes slowly clear the acetaldehyde and the symptoms dissipate. People on drugs such as Antabuse that inhibit ALDH activity might also be subject to meitei-sho, but so far that hasn’t been documented.
What’s likely happening in the Japanese cases is a combination of high carb intake (which the Japanese diet is famous for), yeast infection, and a limited ability to metabolize the alcohol produced – any of these alone probably won’t do the trick. My guess is that even without considering their BAC, auto-brewery sufferers might be in no condition to drive, since they’d be under the influence of acetaldehyde.
The legal implications of all this vary. Generally, driving while impaired for any reason (including tiredness or taking legal medications) is against the law. Ignorance that you’re impaired, which arguably might apply in the case of auto-brewery syndrome, isn’t necessarily a defense – impaired-driving laws in many states don’t require the element of intent. As a practical matter, the potential consequences of EE are of greatest concern to those subject to so-called zero-tolerance laws – mainly drivers under 21, who may face sanctions for driving with a BAC greater than zero, .01, or .02 percent, depending on the state. Those with candidiasis and low ALDH activity (for genetic or pharmaceutical reasons) can exceed those levels. If that describes you, maybe you should think seriously about that skateboard. If not, disregard the wacky factlets and remember that only knuckleheads drink and drive.
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